Applications

Vitrobot Mark IV System from preparing the system with multiple sample types, such as proteins, bacteria, and cells to fulfill your multiple structural biology applications requirements. 

Single particle analysis

Cryo electron tomography

Integrative structural biology

Key Features

The vitrification process

Highly automated vitrification process with enclosed process chamber:

Automated shutter control allows smooth, instant injection of the sample grid into the coolant (liquid ethane or propane). A lift for the container brings the coolant close to the shutter to ensure optimal vitrification.

Synchronous lowering of the coolant container and the grid holder keeps the grid submerged in the coolant and minimizes the risk of contamination prior to transfer ring the sample into a storage box or cryo holder.  

Coolant container with integrated anti-contamination ring.  

Grid transfer from the coolant towards a grid box in the liquid nitrogen environment is semi-automated. 

Sample application

Vitrobot Mark IV System provides precise and flexible control of all critical parameters in the plunge-freezing process:

Small sample volumes can be applied manually with a pipette through a small side port on the left and the right side of the climate chamber.

Both application time and wait time (between application and blotting) are software controlled and can be set in the user interface.

Precisely timed control of multiple sample applications, blotting actions, and vitrification enables time resolved analysis of interactions among separately applied components.

Vitrobot Mark IV System technical specifications

For more detail information of Vitrobot Mark IV System, please visit the website: https://www.thermofisher.com/vn/en/home/electron-microscopy/products/sample-preparation-equipment-em/vitrobot/instruments/vitrobot-mark-iv.html

Or directly contact to ADGroup